Perfluorododecanoic Acid (PFDO)

Perfluorododecanoic acid (PFDO), also known as PFDoDA or C12, is a 12-carbon PFAS carboxylate monitored under UCMR5. It is primarily detected near fluoropolymer manufacturing facilities. Due to its long carbon chain, PFDO has very high bioaccumulation potential. Detection in drinking water is relatively uncommon compared to shorter-chain PFAS, but when found, levels can indicate proximity to significant industrial sources. PFDO is part of the broader UCMR5 monitoring program to characterize the full scope of PFAS contamination in US drinking water.

Where PFDO comes from

Common uses

  • Fluoropolymer processing
  • Specialty surfactants

Industries

  • Chemical manufacturing

Health effects of PFDO exposure

Short-term effects

  • Liver toxicity at high exposures

Long-term effects

  • High bioaccumulation potential
  • Liver damage
  • Immune effects

Most vulnerable populations

  • People near fluoropolymer plants
  • Pregnant women

How to remove PFDO from drinking water

Reverse osmosis
98% removal
Activated carbon
92% removal
Ion exchange
98% removal

See filters certified to remove PFDO and other PFAS.

Is PFDO in your water? – Enter your ZIP at KnowYourExposure to see your local EPA test results.